SCID mice lack T-cells

  1. NOD mice lack B-cells.
  2. NOD/SCID lack both. NOD/SCID/Gamma (NSG) mice also lack NK cell cytotoxicity.

NSG Mouse

NOD/SCID/Gamma (NSG) mice are the preferred host for xenograft experiments. nude mice have more of their (mouse) immune response remaining than do the NOD/SCID or NSG mice.

If you want to mimic the human immune response to your tumor and treatment agent(s), humanize the NSG mouse with human bone marrow, thereby gaining a human immune system.

After human bone marrow graft has been established, inject your tumor and subsequently after it has been established (i.e., has survived the human immune response), then test your drug(s).